Extended Data Fig. 7: Effects of 8-week VB treatment on weight gain and adipose tissue mass in control or Western diet in conventional female mice.
From: Microbial metabolite delta-valerobetaine is a diet-dependent obesogen
Effects of 8-week VB treatment on weight gain and adipose tissue mass in control or Western diet in conventional female mice (n = 5 per treatment). The combination of Western Diet with VB led to approximately a 3-6% increase in body weight compared to Western Diet alone in female mice, however these results were not statistically significant at a p-value threshold of 0.05 (p = 0.14, one-tailed t-test). In control-diet fed female conventional mice (n = 5 per treatment), VB did not increase weight gain (p-value for increase in weight = 0.9803 (1 – 0.0197), one-tailed t-test). VB treatment increased perigonadal visceral adipose tissue (VAT) and posterior subcutaneous adipose (SubQ) tissue mass in conventional female mice fed a Western diet. VB treatment increased interscapular brown adipose tissue (BAT) mass on a control diet but did not increase BAT mass with the Western diet in conventional female mice. One-tailed t-tests with p < 0.05 used to test for an increase in adipose tissue mass following VB treatment.
