Fig. 1: Community amino acid metabolic pathways differ in CDI-susceptible hosts.
From: Oxidative ornithine metabolism supports non-inflammatory C. difficile colonization
a, Experimental design. Samples from patients with diarrhea were collected, classified as healthy-like or dysbiotic and used for a humanized mouse model of CDI13. Mice humanized with healthy-like microbiotas are recalcitrant to developing CDI and associated pathology, whereas mice colonized with communities from dysbiotic, symptomatic patients harbor persistent infections and higher levels of inflammation. RNA-seq was performed on n = 6 mice per group. b, Community-level amino acid metabolic pathways enriched in mice humanized with healthy-like human microbiotas (positive log2fold change and log10adjusted P value) versus dysbiotic (negative). Metabolic pathways involved in ornithine, arginine and polyamine metabolism are colored in red. c, Differential expression of arginine, ornithine and polyamine metabolic pathways after Cd challenge.
