Fig. 8: Liver Psd3 downregulation in mice fed a NASH-inducing diet improved liver histopathology.
From: PSD3 downregulation confers protection against fatty liver disease
C57BL/6 male mice were fed a NASH-inducing diet for a total of 50 weeks and during the last 16 weeks, groups of mice were dosed via once weekly with subcutaneous injections of saline (n = 10 animals), control GalNAc–ASO (n = 9 animals, 5 mg per kg body weight per week) or Psd3 GalNAc–ASO (n = 10 animals, 5 mg per kg body weight per week). Liver sections were stained with haematoxylin and eosin, ORO or picrosirius red according to standard procedures. Consecutive sections were immunohistochemically stained for Col1a1. Representative pictures are presented. Ctr, control.
