Table 2 PSD3 rs71519934 minor allele associated with lower prevalence of liver disease in the LBC (N histological data = 1,951)

From: PSD3 downregulation confers protection against fatty liver disease

 

186L

L186T

186T

P value

OR

CI

N

917

796

238

    

Steatosis presence, n (%)

778 (85)

603 (76)

170 (71)

5.9 × 10−6

0.67

0.57

0.80

Fibrosis presence, n (%)

536 (58)

417 (52)

121 (51)

0.006

0.82

0.72

0.94

Inflammation presence, n (%)

596 (65)

420 (53)

118 (50)

9.9 × 10−7

0.70

0.61

0.81

Ballooning presence, n (%)a

338 (39)

246 (34)

68 (31)

0.002

0.79

0.68

0.92

  1. The association was tested by binary logistic regression analysis under an additive genetic model adjusted by age, gender, BMI, centre of recruitment and number of PNPLA3 mutant alleles. Presence of steatosis, fibrosis, inflammation or ballooning was defined as the relative degree >0.
  2. CI, confidence interval; OR, odds ratio.
  3. aData available for n = 1,805.
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