Extended Data Fig. 10: Effect of 2-HG on ME2-mediated tumour growth, and TP53 mutation correlates with ME2 mRNA expression, and mutations of D2HGDH, L2HGDH and IDH1.
From: Malic enzyme 2 maintains protein stability of mutant p53 through 2-hydroxyglutarate
a, Schematic summarizing the dual characteristics of ME2 enzymatic functions, and a role for 2-HG in preventing mutant p53 degradation by Mdm2. Whether ME2 produces pyruvate or 2-HG may dependent on cellular demands of these metabolites, and viability of sufficient NADPH. b, Results from fisher’s exact test showed the group with higher expression level of ME2 was significantly higher TP53 mutation frequency. Please see Methods for details. c, Correlation analysis of mutant p53 and ME2 expression in in human cancer patients from The Cancer Genome Atlas (TCGA) of pan cancer. The color shades of the circles represent the expression of mutant p53 and the blue line represents the expression of ME2. d-f, Correlation of TP53 mutation frequency and mutation status of IDH1(d), D2HGDH (e) or L2HGDH (f) in human cancer patients from The Cancer Genome Atlas (TCGA) of pan cancer was analyzed via cBioPortal for Cancer Genomics. Data in b-f are means ± SD. P values were determined by Fisher’s exact test.
