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CANCER METABOLISM

Methylmalonic acid: an age-related metabolite that drives tumour aggressiveness

Nature Metabolism volume 4, pages 412–413 (2022)Cite this article

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Oncometabolites are pro-tumourigenic metabolites that can determine tumour aggressiveness. This study found that methylmalonic acid is upregulated in breast lung metastasis and metastatic cancer cells. Methylmalonic acid alters the gene expression profile to induce a pro-metastatic phenotype in breast and lung cancer cells.

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Fig. 1: Methylmalonic acid promotes tumour aggressiveness.

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Authors and Affiliations

  1. Cancer Research UK Beatson Institute, Glasgow, UK

    Emily J. Kay & Sara Zanivan

  2. Institute of Cancer Sciences, University of Glasgow, Glasgow, UK

    Sara Zanivan

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  1. Emily J. Kay
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  2. Sara Zanivan
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Correspondence to Emily J. Kay or Sara Zanivan.

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The authors declare no competing interests.

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Kay, E.J., Zanivan, S. Methylmalonic acid: an age-related metabolite that drives tumour aggressiveness. Nat Metab 4, 412–413 (2022). https://doi.org/10.1038/s42255-022-00540-w

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