Extended Data Fig. 6: Expression analysis of the genes encoding PDH complex and the PDH regulatory machinery in nTregs of aged mice.
From: PARK7/DJ-1 promotes pyruvate dehydrogenase activity and maintains Treg homeostasis during ageing
a, mRNA expression of the genes (Pdks) encoding PDH kinases and the genes (Pdps) encoding pyruvate dehydrogenase phosphatases in Tregs freshly isolated from aged Dj-1 KO and age- and gender-matched WT littermates (n=3/group). **P=0.00420, *P=0.0348, and *P=0.0362. b, mRNA expression of the genes encoding several PDH complex subunits in Tregs freshly isolated from aged Dj-1 KO and WT littermates. Results are the summary of the microarray datasets (from 3 mice each group). Data are mean± s.d. P values are determined by two-tailed Student’s t-test. ns or unlabeled, not significant, *P<=0.05, **P<=0.01 and ***P<=0.001.
