Fig. 2: Hepatic senescence markers are associated with inflammation and hepatic fibrosis.
From: BMP4 and Gremlin 1 regulate hepatic cell senescence during clinical progression of NAFLD/NASH
a,c, Circulating levels of IL-6 and adiponectin (a), and RT–qPCR analysis of hepatic inflammatory markers IL-1β and IL-6 (c) in lean individuals, patients with NAFLD and patients with NASH. b,d,e–h, Correlation comparisons of mRNA levels of hepatic senescence markers with IL-1β (b) and IL-6 (d) mRNA levels, and with parameters of histological grading: steatosis score (e), ballooning score (f), lobular inflammation score (g) and fibrotic score (h). Data were collected in lean participants (n = 11–12), patients with NAFLD (n = 21–22) and patients with NASH (n = 22–24). Associations were determined using Pearson or Spearman correlation analysis. Values are mean ± s.e.m. Statistical significance was determined using Kruskal–Wallis with post hoc Dunn’s test.
