Extended Data Fig. 8: Type-A and Type-B UPV are associated to distinct DNA methylation patterns.
From: Independent phenotypic plasticity axes define distinct obesity sub-types
a, heat map showing the differentially DNA methylated sites among ‘heavy’ and ‘light’ cotwins belonging to the indicated groups identified in the TwinsUK cohort. SeSAMe cutoffs: adjusted p-value < 0.05; effect size > 0.05. Dark-gray and black boxes highlight DNA methylation enrichment in either the ‘light’ or ‘heavy’ cotwin, respectively. b, Venn diagram showing the overlap between differentially DNA methylated sites from the indicated cotwin groups and highlighting the specificity of these epigenetic profiles. c, Barplots showing the amount of differentially methylated regions (DMRs) among ‘heavy’ and ‘light’ cotwins belonging to the indicated groups identified in the TwinsUK cohort. Only in Type-B UPV, DMRs were detected. Dark-gray and black bars highlight DNA methylation enrichment in either the ‘light’ or ‘heavy’ cotwin, respectively.
