Extended Data Fig. 2: Insulin decreased InsR protein levels.
From: Insulin induces insulin receptor degradation in the liver through EphB4
a-c, Dose-dependent effect of insulin (6 h) on InsR protein levels in primary hepatocytes from C57BL/6J mice. n = 3 cells examined over 2 independent experiments in b, c. d-f, Time-dependent effect of insulin (100 nM) on InsR protein levels in primary hepatocytes from C57BL/6J mice. n = 3 cells examined over 2 independent experiments in e, f. For statistical analysis in b-c and e-f, comparisons were versus related controls, using two-sided Student’s t-test. p values in b denoted by asterisks (from left to right): p = 0.020, p = 0.024, p = 0.012, p = 0.0043. p values in c denoted by asterisks (from left to right): p = 0.033, p = 0.021, p = 0.012, p = 0.013, p = 0.0014. p values in e denoted by asterisks (from left to right): p = 0.010, p = 0.0053, p = 0.0020. p values in f denoted by asterisks (from left to right): p = 0.013, p = 0.031, p = 0.014, p = 0.029, p = 0.043. Values are presented as the mean ± SEM.
