Extended Data Fig. 1: Genetic variation affects COX7A2L expression in human muscle.
From: COX7A2L genetic variants determine cardiorespiratory fitness in mice and human
a. Heatmap of ontology terms and pathways associated with COX7A2L expression in different human tissues. All terms significantly associated with COX7A2L expression in at least one tissue (GMAS >=0.268, <=-0.268) are shown. Ontology terms and tissues are organized by similarity. Boxed terms are indicating representative ontology term with high correlation with COX7A2L. Data from https://systems-genetics.org33. b. Schematic representation of the GTEx cis-eQTL analysis for the COX7A2L gene. Variants located within ±1 Mb from the COX7A2L gene and affecting its expression were considered cis-eQTLs. c. Correlation between the number of samples per tissue and the number of significant COX7A2L cis-eQTLs per tissue. Two-sided Spearman r and p value are shown above the graph. d. COX7A2L cis-eQTLs overlap among 5 representative tissues; next to the tissue name, the total number of cis-eQTLs is shown in parenthesis, percentages indicate the proportion of tissue-specific cis-eQTLs.
