Extended Data Fig. 4: Grb10 enhances leptin sensitivity in AgRP neurons.
From: Hypothalamic Grb10 enhances leptin signalling and promotes weight loss
a-b. Representative images (a) and quantification (b) for leptin-induced pSTAT3 in the VMH of control (n = 5) and AgRP-Grb10-KD (n = 5) mice treated with saline or leptin. c-d. Representative images (c) and quantification (d) for leptin-induced pSTAT3 in the VMH of control (n = 5) and AgRP-Grb10-OE (n = 5) mice treated with saline or leptin. Scale bar = 100 µm. Data are expressed as mean ± SEM. Two-tailed Student’s t test (b, d).
