Extended Data Fig. 3: The dominant negative Rac1-T17N mutant reduces the promoting effect of WT and L4 LDHA on colony formation, migration and invasion of breast cancer cells. | Nature Metabolism

Extended Data Fig. 3: The dominant negative Rac1-T17N mutant reduces the promoting effect of WT and L4 LDHA on colony formation, migration and invasion of breast cancer cells.

From: Metabolic enzyme LDHA activates Rac1 GTPase as a noncanonical mechanism to promote cancer

Extended Data Fig. 3: The dominant negative Rac1-T17N mutant reduces the promoting effect of WT and L4 LDHA on colony formation, migration and invasion of breast cancer cells.

a-c, Hs578T and SK-BR3 cells with ectopic expression of WT or L4 LDHA were transduced with control or Rac1-T17N expression vectors for colony formation (a), migration (b) and invasion (c) assays. Data represent mean ± s.d. (n = 6 independent experiments), two-way ANOVA followed by Tukey’s or Bonferroni’s test. *: P < 0.0001.

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