Extended Data Fig. 3: The dominant negative Rac1-T17N mutant reduces the promoting effect of WT and L4 LDHA on colony formation, migration and invasion of breast cancer cells. | Nature Metabolism

Extended Data Fig. 3: The dominant negative Rac1-T17N mutant reduces the promoting effect of WT and L4 LDHA on colony formation, migration and invasion of breast cancer cells.

From: Metabolic enzyme LDHA activates Rac1 GTPase as a noncanonical mechanism to promote cancer

Extended Data Fig. 3: The dominant negative Rac1-T17N mutant reduces the promoting effect of WT and L4 LDHA on colony formation, migration and invasion of breast cancer cells.The alternative text for this image may have been generated using AI.

a-c, Hs578T and SK-BR3 cells with ectopic expression of WT or L4 LDHA were transduced with control or Rac1-T17N expression vectors for colony formation (a), migration (b) and invasion (c) assays. Data represent mean ± s.d. (n = 6 independent experiments), two-way ANOVA followed by Tukey’s or Bonferroni’s test. *: P < 0.0001.

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