Extended Data Fig. 4: LDHA but not Rac1 is localized in invadopodia in breast cancer cell lines. | Nature Metabolism

Extended Data Fig. 4: LDHA but not Rac1 is localized in invadopodia in breast cancer cell lines.

From: Metabolic enzyme LDHA activates Rac1 GTPase as a noncanonical mechanism to promote cancer

Extended Data Fig. 4

HS578T and MDA-MB231 cells seeded on gelatin-coated coverslips were labeled with anti-LDHA or Rac1 in far-red, anti-Tks5 in green and phalloidin (to stain F-actin) in red. The co-localization of Tks5 and F-actin in a punctate manner in cells was used as an indication of invadopodia formation. Arrows indicate invadopodia in cells. Scale bars: 20 μm. Data represent three repeats with similar results.

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