Extended Data Fig. 8: The effect of small-molecule inhibitor treatments on the body weights of tumor-bearing mice.
From: Metabolic enzyme LDHA activates Rac1 GTPase as a noncanonical mechanism to promote cancer
a, Small-molecule inhibitor treatments did not significantly affect the body weights of female nude mice bearing orthotopic tumors formed by WT Hs578T cells. b, Small-molecule inhibitor treatments did not significantly affect the body weights of female BALB/c mice bearing orthotopic tumors formed by 4T1 cells transduced with the control lentiviral shRNA vector. Mice were treated with FX11 (1 mg/kg/day; i.p.; once/day) and/or NSC23766 (1.5 mg/kg/day, i.p.; once/day), or vehicle (−). Mice with Hs578T tumors were treated for 3 weeks and mice with 4T1 tumors were treated for 2 weeks. The body weights of mice were measured and recorded at the days indicated. Data represent mean ± s.d. n=8 mice/group. Statistical differences were determined by two-way ANOVA followed by Tukey’s test.
