Extended Data Fig. 1: LDHA overexpression and its association with clinical outcomes in different subtypes of breast cancers classified by the status of ER, PR or HER2. | Nature Metabolism

Extended Data Fig. 1: LDHA overexpression and its association with clinical outcomes in different subtypes of breast cancers classified by the status of ER, PR or HER2.

From: Metabolic enzyme LDHA activates Rac1 GTPase as a noncanonical mechanism to promote cancer

Extended Data Fig. 1: LDHA overexpression and its association with clinical outcomes in different subtypes of breast cancers classified by the status of ER, PR or HER2.The alternative text for this image may have been generated using AI.

a-c, The increased LDHA mRNA levels in different subtypes of breast cancers compared with matched adjacent non-tumor breast tissues. The data were obtained from TCGA and the P-value was analyzed by two-tailed paired Student’s t-test. d-f, High LDHA mRNA expression is associated with poor relapse-free survival in patients with different subtypes of breast cancers. The data were obtained from Kaplan-Meier plotter (http://kmplot.com) and analyzed by the log-rank (Mantel–Cox) test. ER: estrogen receptor; PR: progesterone receptor.

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