Extended Data Fig. 4: Effect of the TAL-AR axis on de novo GSH biosynthesis.
From: Cytosolic aldose metabolism contributes to progression from cirrhosis to hepatocarcinogenesis
a, Measurement of GSH synthesis intermediates in liver of WT (n = 4), TALKO (n = 4), ARKO (n = 5), and DKO mice (n = 5). *, p < 0.05 relative to WT using two-tailed t-test. Brackets indicate differences between mouse strains at p < 0.05. b, Enrichment of [M1-13C]-PGA, [M2-13C]-PGA, and [M5-13C]-GSH in hepatocytes of WT (n = 4), TALKO (n = 4), ARKO (n = 4), and DKO mice (n = 4) labeled with [U-13C]-glutamine (DLM-1150-0.5, Cambridge Isotope Laboratories; Cambridge, MA) for 24 hours. *, p < 0.05 relative to WT using one-tailed t-test. c, Schematic diagram of GSH biosynthesis involving substrates regulated by the TAL-AR axis.
