Sepsis takes a severe toll in the heart and can in some instances induce irreversible dysfunction. Zhang et al. discover a subset of macrophages that protects the septic heart by removing inflammogenic material released by cardiomyocytes.
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A.H. is a paid consultant for Flagship Pioneering, Inc. J.A.N.-A. declares no competing interests.
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Nicolás-Ávila, J.Á., Hidalgo, A. TREM2+ macrophages are guardians of the heart. Nat Metab 5, 13–15 (2023). https://doi.org/10.1038/s42255-022-00712-8
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DOI: https://doi.org/10.1038/s42255-022-00712-8
