Extended Data Fig. 2: Poor insulin sensitivity in mice administered TPN.
From: Total parenteral nutrition impairs glucose metabolism by modifying the gut microbiome
n = 8 animals over 3 independent experiments. (a) Body weight changes in TPN-treated/chow-fed mice (P = 0.0229 for 3rd day, P = 0.0010 for 4th day, P = 0.0307 for 5th day, P = 0.0045 for 6th day, P = 0.0447 for 7th day). b–c. Area under the curve values for IPGTTs (b), and for IPITTs (c) in Chow and TPN groups. (d) Body composition of different groups of mice. (e) Venn diagram showing the potential central role of insulin resistance in glucose dysmetabolism, lean mass loss, and clinical complications during parenteral nutrition. Data are shown as mean ± S.D. (a), median (solid line) with 1st (lower dotted line) and 3rd (upper dotted line) quartiles in violin plot (b-d). P-Values are determined by Mann-Whitney test (a-d). All statistical tests are two-sided.
