Extended Data Fig. 5: Changes in levels of indole derivatives may underlie the association between reduced Lactobacillus abundance and glucose dysmetabolism.
From: Total parenteral nutrition impairs glucose metabolism by modifying the gut microbiome
n = 5 animals over 3 independent experiments. (a) Heatmap showing the top 15 differential metabolites. (b) The top 10 most enriched Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways related to the differential metabolites. (c) Body weight changes during IAA treatment in mice (P-value were 0.0459 at 3rd day, 0.0439 at 9th day, 0.0150 at 11th day, 0.0088 at 12th day, 0.0088 at 13th day, 0.0088 at 14th day). (d) The blood concentration of IAA at 1st, 4th, 8th, 12th hour after intraperitoneal injection of IAA in mice (P- value were 0.0239, 4.6E-07, 0.0039 from left to right). (e) The blood concentration of IAA at the samples harvest time point. f-g. Area under the curve values for IPGTTs (f), and IPITTs (g). (h) Body composition of different groups of mice. Data are shown as mean ± S.D. (c, d), median (solid line) with 1st (lower dotted line) and 3rd (upper dotted line) quartiles in violin plot (e-h). P-Values are determined by GO enrichment analysis (b), Mann-Whitney test (c, d, h), Kruskal-Wallis test with correction by Dunnett’s t test (e-g). All statistical tests are two-sided.
