Extended Data Fig. 7: ABCA1 sustains a lysosomal mTORC1 recruitment during senescence.
From: Lysosomal control of senescence and inflammation through cholesterol partitioning
Immunocytochemistry of the indicated proteins (left). Scale bar, 50 μm. Pearson’s correlation coefficient for colocalization of mTOR and LAMP2 in the indicated cell lines during senescence upon amino acid starvation (2 h) and refeeding (30 m) (right, n = 3 biologically independent experiments, 10–23 randomly chosen individual cells from each experiment, box plots show the 1st and 3rd quartiles; whiskers show the minimum and maximum values, one-way ANOVA test with Tukey’s multiple comparisons test). PRO and SEN denote sham-treated proliferating and senescent cells.
