Extended Data Fig. 5: Effect of Na-L-lactate on body weight in GPR81 knockout and wild-type mice. | Nature Metabolism

Extended Data Fig. 5: Effect of Na-L-lactate on body weight in GPR81 knockout and wild-type mice.

From: The anorectic and thermogenic effects of pharmacological lactate in male mice are confounded by treatment osmolarity and co-administered counterions

Extended Data Fig. 5: Effect of Na-L-lactate on body weight in GPR81 knockout and wild-type mice.

a-d, DIO GPR81 knockout mice (GPR81-KO) and wild-type control mice (GPR81-WT) treated daily with injections of 2 g/kg Na-L-lactate or iso-osmolar NaCl for 15 days while single-housed in standard cages (mouse study 16 in Methods). a, Change in absolute body weight in GPR81-KO mice during the study (Na-L-lactate n = 6 mice, NaCl n = 6 mice). b, Change in absolute body weight in GPR81-KO mice after 15 days (Na-L-lactate n = 6 mice, NaCl n = 6 mice). c, Change in absolute body weight in GPR81-WT mice during the study (Na-L-lactate n = 7 mice, NaCl n = 6 mice). d, Change in absolute body weight in GPR81-WT mice after 15 days (Na-L-lactate n = 7 mice, NaCl n = 6 mice). Data shown as the mean ± SEM.

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