Extended Data Fig. 7: Analysis of GAPDH mutant mice.
From: The GAPDH redox switch safeguards reductive capacity and enables survival of stressed tumour cells
(a) Mapping of differential protein abundance in the kidney on a metabolic pathway chart (iPath). Blue lines highlight metabolic transformations significantly downregulated in GAPDH mutant kidneys. Red lines highlight metabolic transformations significantly upregulated in GAPDH mutant kidneys. The line thickness indicates fold change. (b) Gene set enrichment analysis of proteins differentially expressed in the GAPDH mutant heart. Mapping to KEGG (Kyoto Encyclopedia of Genes and Genomes) pathways. Blue bars: gene sets with decreased representation in mutant heart. Red bars: gene sets with increased representation in mutant heart. Based on n = 6 biological replicates. (c) Mapping of differential protein abundance in the heart on a metabolic pathway chart (iPath). Blue lines highlight metabolic transformations significantly downregulated in GAPDH mutant kidneys. Red lines highlight metabolic transformations significantly upregulated in GAPDH mutant kidneys. The line thickness indicates fold change.
