Extended Data Fig. 8: Deletion of Sirt4 prevented brain edema induced by CCl4.
From: Amino acids downregulate SIRT4 to detoxify ammonia through the urea cycle
Brain images were obtained from wild-type and Sirt4-/- C57 mice after CCl4 treatments for 10 weeks; number of mice were 10 for each experimental group. Brain edema indicated by asymmetry hyper-intensity was pointed out by red arrows.
