Extended Data Fig. 9: Deletion of Sirt4 prevented mouse exploratory and locomotor activity loss induced by CCl4.
From: Amino acids downregulate SIRT4 to detoxify ammonia through the urea cycle
a-c. Mobile time (a), immobile time (b), and mean speed (c) were determined via the open field test in wild-type and Sirt4-/- C57 mice treated with our without CCl4 (n = 10 biologically independent samples, a: P = > 0.05, 0.0025; b: P = > 0.05, 0.0071; c:P = > 0.05, 0.0269). d-g. Total distance (d), novel arm exploration time (e), old arm distance (f), and old arm exploration time (g) were determined via the Y-maze test in wild-type and Sirt4-/- C57 mice treated with or without CCl4 (n = 10 biologically independent samples, d: P = > 0.05, 0.0060; e: P = > 0.05, 0.0145; f:P = > 0.05, > 0.05; g: P = > 0.05, 0.0142).
