Extended Data Fig. 10: Schematic diagram of amino acids-regulated SIRT4 coordinates ammonia detoxification and urea cycle.
From: Amino acids downregulate SIRT4 to detoxify ammonia through the urea cycle
GCN2 senses amino acids to downregulate SIRT4 expression, which suppresses ammonia detoxification by inhibiting CP incorporation into the urea cycle by inhibiting OTCCP-K307 that activates OTC.
