Extended Data Fig. 5: Mpc1 depletion reduces lactate fueling of the TCA cycle. | Nature Metabolism

Extended Data Fig. 5: Mpc1 depletion reduces lactate fueling of the TCA cycle.

From: Mitochondrial pyruvate carrier-mediated metabolism is dispensable for the classical activation of macrophages

Extended Data Fig. 5: Mpc1 depletion reduces lactate fueling of the TCA cycle.The alternative text for this image may have been generated using AI.

(a) to (d) U-[13C]-Lactate labeled TCA cycle metabolites in Mpc1fl/fl and Mpc1ΔLysM BMDMs (n = 5 biologically independent samples). (e) Gating strategy for peritoneal macrophages.Data are representative of two independent experiments (a to d). P values were calculated using unpaired, two-sided Student’s t-test. Data are presented as mean ± s.e.m.

Back to article page