Extended Data Fig. 7: Diverse cancer types likely drove the association between histamine and mast cells.
From: A multimodal atlas of tumour metabolism reveals the architecture of gene–metabolite covariation
(A) Box plots of concordance of histamine – mast cells across 13 datasets. The data is displayed as a boxplot, in which the box bounds represent the 25th to the 75th percentile, with the median shown as a line in the center. The bottom whisker extends to the smallest value that is not an outlier, and the upper whisker extends to the largest value that is not an outlier. (B) Scatterplots comparing expression of the mast cell signature without HDC to histamine abundance. Two-tailed p-values were estimated from the unscaled concordance value’s z-score (see Methods). (C) Heatmap of single cell gene expression data for HDC across datasets from the TISCH2 database85,86. Expression is standardized to z-scores across cell types in a dataset. Considering only datasets in which mast cells are identified, mast cells exhibit highest expression of HDC.
