Extended Data Fig. 8: The association between kynurenine and dendritic cells was not solely dependent on IDO1 itself.
From: A multimodal atlas of tumour metabolism reveals the architecture of gene–metabolite covariation
(A) Heatmap of single cell gene expression data for IDO1 across datasets from the TISCH2 database85,86. Expression is standardized to z-scores across cell types in a dataset. Considering only datasets in which dendritic cells are identified, dendritic cells exhibit the highest expression of IDO1. (B) Scatterplots comparing expression of the aDC signature without IDO1 to kynurenine abundance. Two-tailed p-values were estimated from the unscaled concordance value’s z-score (see Methods).
