Fig. 6: A subset of metabolites associates with specific immune cell lineages.
From: A multimodal atlas of tumour metabolism reveals the architecture of gene–metabolite covariation
a, Volcano plot of cell-type signature–metabolite interactions. The rug plot at the bottom highlights the numerous associations with quinolinate. b, Manhattan plot of adjusted concordance P values between metabolites and cell types. c, Histamine associates with the abundance of mast cells across most datasets of the CAMP. d, Bar plot of adjusted concordance P values of metabolites correlated with the mast cell gene signature. The red dashed line indicates the significance cut-off of 0.05. Metabolites labelled in red are associated with histamine metabolism. e, HDC expression strongly associates with mast cell abundance across the CAMP. f, Kynurenine abundance associates with an aDC signature across the CAMP. In a–f, two-tailed P values were estimated from the z-scores of the unscaled concordance values (Methods) and were corrected for multiple testing using the Benjamini–Hochberg method.
