Extended Data Fig. 4: Sertraline inhibits BAT activity in supraclavicular and paraspinal depots.
From: The serotonin transporter sustains human brown adipose tissue thermogenesis
(a-h) 18F-FDG uptake by BAT was categorised into either supraclavicular/ cervical/ axillary (grouped as SCV) or paraspinal regions of interest on placebo (closed circles) and sertraline (closed squares) phases (a-f n = 15 and g-h n = 12). (i) Left and right supraclavicular (SCV) skin temperatures during warm (pink columns) and cold exposure (blue columns, both n = 15). Left SCV temperature was lower than right SCV during cold exposure but the effect of sertraline was similar in both SCV regions. (j) The correlation in the change in total 18F-FDG uptake by BAT (BAT activity) between placebo and sertraline phases with the change in cold-induced thermogenesis (CIT) between phases (n = 15). (k-i) Circulating (k) sertraline and (l) norsertraline drug concentrations (n = 15), lines detail the median values. Male and female subjects are depicted by black and red circles / squares respectively. Data are mean ± SEM and were analysed using (a-f, k-l) Wilcoxon signed-rank test, (g-h) paired t test, (i) two-way repeated measures ANOVA or (j) Pearson correlation. Significant P values are detailed in the respective panels.
