Fig. 4: Sertraline does not alter hormonal responses to cold or 18F-FDG uptake by skeletal muscle.
From: The serotonin transporter sustains human brown adipose tissue thermogenesis
a–d, Circulating concentrations of noradrenaline (a), NEFAs (b), insulin (c) and glucose (d) (all n = 15 biologically independent participants per group) on sertraline (black squares) and placebo (black circles) phases (Extended Data Fig. 3a). e,f, Serotonin concentrations at baseline in platelets (e) and platelet-poor plasma (f) (both n = 13 per group). Lines depict the median (e) and mean (f) values. g–l, 18F-FDG uptake during cold exposure was quantified in pectoralis major (g), psoas major (h), sternocleidomastoid (i), longus colli (j) and trapezius skeletal (k) muscles, in addition to abdominal subcutaneous WAT (l) (all n = 15 per group) on both placebo (circles) and sertraline (squares) phases. Male and female participants are depicted by black and red circles/squares, respectively. Data are mean ± s.e.m. and were analysed by two-way repeated measures ANOVA (a–d), Wilcoxon signed-rank test (e) and paired t-test (f–l). Significant P values are detailed in the respective panels.
