Extended Data Fig. 5: Different resolution β-cell states correspond to biological conditions.
From: Delineating mouse β-cell identity during lifetime and in diabetes with a single cell atlas
(a) Coarse β-cell states, including low-quality clusters. (b) Fine β-cell states, including low-quality clusters. (c) and (d) Coarse and fine, respectively, β-cell state proportions in each sample, also displaying corresponding sample metadata. Sample names are given as study_sampleDescription_sampleIdentifier. (e) Comparison of coarse and fine β-cell state annotation given as a normalized distribution of each fine state across coarse states. (f) A UMAP embedding of male and female β-cells across ages. Colored in are cells from datasets that have mixed sexes within samples, other β-cells are displayed as a background. (g) Expression of Cfap126 (Flattop gene) across cell populations that were sorted based on the Flattop reporter system. Abbreviations: hMT - high mitochondrial transcript read fraction.
