Extended Data Fig. 9: Healthy β-cells contain five distinct variable gene groups.
From: Delineating mouse β-cell identity during lifetime and in diabetes with a single cell atlas
(a) Pairwise comparison of the normalized activity of gene groups on β-cells from healthy samples shown as kernel-estimated density plots colored by study. Lines represent regions containing 5, 34, 67, 95 and 99% of cells. Axes represent the activity of the compared gene groups. (b) Mean gene group activity within coarse β-cell clusters, normalized across clusters. (c) Per-sample distribution of normalized gene group activities in β-cells shown as cumulative density functions. (d) Localization of cells with the highest activity of the five gene groups on the atlas β-cell UMAP for individual health adult atlas samples (named as: dataset sample_metadata sample_name) and the healthy adult samples from the external dataset (Feng, GSE137909) mapped on top of the atlas. (e) Localization of virgin and non-virgin β-cells from Feng (GSE137909) dataset on the integrated atlas UMAP as annotated in the original publication.
