Fig. 6: Lipid–cytokine associations.
From: Dynamic lipidome alterations associated with human health, disease and ageing
a–e, Network of 1,245 significant (BH FDR < 5%) lipid–cytokine associations, indicating positive (red) and negative (blue) associations calculated across 1,180 samples, across all lipids (a) and for PCs (b), PEs (c), LPCs (d) and LPEs (e). Networks were pruned based on a BH FDR of 5% for coefficients determined in linear mixed-effects models. Colour indicates lipid class; edge width represents coefficients; and node size represents node connectivity (popularity). The network was assembled using the ‘graphopt’ layout algorithm. f, Fisher’s exact test enrichment analysis comparing the physicochemical properties of lipids (y axis), at the subclass, global FA and individual FA level, that are associated with a particular cytokine (x axis). The analysis was performed for TAGs only (i), for all non-TAG lipids (ii) and across all lipids (iii). Enrichments (log2(odds)) among lipids with positive β coefficients (BH FDR < 10%) are indicated in red; enrichments (log2(odds)) among lipids with negative β coefficients (BH FDR < 10%) are indicated in blue; black denotes cases for which a certain property was enriched in both populations (positive and negative associations). log2(odds) values are depicted when the respective annotation was significantly associated with a BH FDR of <5%. Infinite log2(odds) values are imputed with 0.5× the positive/negative log2(odds) values determined across all data. IL-1Ra, IL-1 receptor antagonist; ICAM1, intercellular adhesion molecule 1; SDF1⍺, stromal cell-derived factor 1⍺; RANTES, regulated on activation, normal T cell expressed and secreted; PDGF-BB, platelet-derived growth factor-BB; GRO⍺, growth-regulated ⍺ protein; FasL, Fas ligand; TRAIL, tumour necrosis factor-related apoptosis-inducing ligand.
