Extended Data Fig. 9: Evaluation of AAV expression in the brain and peripheral organs of 5XFAD mice. (Related to Fig. 6). | Nature Metabolism

Extended Data Fig. 9: Evaluation of AAV expression in the brain and peripheral organs of 5XFAD mice. (Related to Fig. 6).

From: Alleviating symptoms of neurodegenerative disorders by astrocyte-specific overexpression of TMEM164 in mice

Extended Data Fig. 9: Evaluation of AAV expression in the brain and peripheral organs of 5XFAD mice. (Related to Fig. 6).The alternative text for this image may have been generated using AI.

a, Representative images showing the expression of AAV-sGFAP-Tmem164-P2A-mCherry-WPRE in different brain regions of 9-month-old 5XFAD mice at 6 months after AAV injection. Scale bar, 20 μm. b, Representative images showing the expression of AAV-sGFAP-Tmem164-P2A-mCherry-WPRE in the peripheral organs of 9-month-old 5XFAD mice at 6 months after AAV injection. Scale bar, 20 μm. c, Percentage of mCherry-positive astrocytes in different brain regions or mCherry-positive cells in the peripheral organs of 5XFAD mice, n = 3 mice per group. Data were presented as mean ± SEM.

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