Extended Data Fig. 5: Details of metabolite behavior and inhibitor sensitivity in recovery from stimulation.
(a) Schematic for the area under the curve (AUC) calculations. (b) Mean intensity of the Ca2+ responses before, during KCl stimulation and during recovery in absence and presence of forodesine (Foro) and G6PDi. Box extends from 25th to 75th percentile, middle line represents the median, whiskers indicate min to max; n = 10–11 mice. (c) The levels of pentoseP,(d) phosphocreatine (PCreatine), (e) ATP and (f) AMP in relation to the AUC of Ca2+ imaging in the same slice in presence of forodesine (Foro; 20 µM) or G6PDi (50 µM) (n = 10–11 mice). Whiskers indicate min to max. Note that here the control was also KCl stimulated.
