Extended Data Fig. 3: Divergent predicted motif activities of transcription factors in untrained and trained WT muscle.
From: Molecular control of endurance training adaptation in male mouse skeletal muscle
a, Number of motifs of transcription factors from ISMARA that have an increased or decreased activity (z-score >1.96) per time point in an untrained (light gray) and trained (dark gray) muscle after an acute maximal exercise bout. b, Venn diagram of all the predicted motifs that are changes in untrained (light gray) and trained (dark gray) muscle after an acute exercise bout. c-d, Trajectories of motif activity of transcription factors from ISMARA in untrained (light gray) and trained (dark gray) muscle post-exercise that are either specific to training status (c) or show an exacerbation after training (d). e, Example of a possible transcriptional cascade including a top predicted transcription factor by ISMARA and one of the downstream targets (gene expression and motif activities). Exact FDR-values of RNA-seq data and z-scores of ISMARA data are displayed in the Source Data file. Data from 5 biological replicates. Data represent means ± SEM. Statistics of RNA-seq data were performed with the CLC genomics workbench software. * indicates difference to Ctrl (pre-exercise condition); *<0.05 (for motif activity: * z-score >1.96); ***<0.001. See also Fig. 2; Supplementary Table 4.
