Extended Data Table 3 Summary of Change from Baseline in Plasma and Urine Phe metabolites from Biomarker study

From: Efficacy and safety of a synthetic biotic for treatment of phenylketonuria: a phase 2 clinical trial

  1. Analysis of unlabeled Phe metabolites on Days 7 and 15 for Arm 1, SYNB1618 and Arm 2 SYNB1934 compared to baseline. Change in plasma TCA AUC (µM*hr) for 0–4h following overnight fast and low Phe breakfast on days 7 and 15. Urinary total amount HA excreted for 0–4h following overnight fast and low Phe breakfast on days 7 and 15.
  2. adata expressed as change from baseline to specified Day as LS mean in units of hr*µM and noting number of patients evaluated. Patient number evaluated at each time point is shown.
  3. bdata expressed as change from baseline to specified Day as LS mean in mmol units and noting number of patients evaluated. Patient number evaluated at each time point is shown.
  4. TCA = trans-cinnamic acid, HA = hippuric acid, LS = least squares, AUC = area under the curve, CI = confidence interval
  5. Source data
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