Extended Data Fig. 5: Comparison of the secretory capacity of specific cell types with RRβ cells.

a, The proportion of various cell types classified based on their Ca2+ dynamics in relation to RRβ cells. b, The definition of 1st responder cells and 2nd follower cells, along with hub cells and leader cells. The left box presents the 1st responders and second responders; the right box portrays hub cells and leader cells. c, A representative functional connectivity map in a single male islet, with red dots symbolizing the hub cells. d, The distribution of connection numbers for different cells within an islet; the right panel depicts the log-log plot shown on the left panel. The current plot indicates that the Ca2+ connectivity map does not follow the power law distribution, which would be represented as an inverse linear relationship within the log-log plot.