Extended Data Fig. 6: Both δ- and α- cell influence β-cell secretion with the islet.
a. A representative example of fusion events from islet 1 in c, during the initial round of glucose stimulation and the subsequent round with 10 nM MK4256. b, A representative example of fusion events from islet 5 in c, during the initial round of glucose stimulation and the second round with 200 nM CYN 154806. c, A tabular representation detailing fusion events from islets treated with either of the SSTR antagonists. Islet 3 isolated from male mouse, and other islets isolated from female mice. d, A typical example of insulin granule fusion evoked by 18.2 mM glucose (upper, male) or with 1 μM MK0893 and 1 μM Exendin9-39 (down, male). e, Total number of fusion events evoked by 18.2 mM glucose (Control, n = 5 islets from 3 male mice) or with 1 μM MK0893 and 1 μM Exendin9-39 (MK+Ex, n = 4 islets from 3 male mice). Data was expressed as mean ± s.e.m. and analyzed by two-sided unpaired Student t-test, ** p < 0.01.
