Extended Data Fig. 4: Muscle loss due to Bcl6 deletion is associated with reduced muscle function.
From: Transcriptional programming of translation by BCL6 controls skeletal muscle proteostasis
(a, b) Absolute (left) and lean body mass normalized (right) forelimb grip strength measured in (a) 13-week old n = 7 Bcl6fl/fl and n = 10 Bcl6MKO female mice and (b) n = 6 Cre+ oil, n = 8 Cre- tmx and n = 8 Bcl6i-MKO female mice twelve weeks after tamoxifen or oil treatment. Whiskers in the boxplot show min to max values with line at the median and box representing the first to third quartile values. (c) Maximum tetanic force for the tibialis anterior (TA) muscle from 13-week old n = 3 Bcl6fl/fl and n = 2 Bcl6MKO female mice (P-value for maximum force = 0.0311 by unpaired, two-tailed t-test with Welch correction). (d, e) Distance and time run on a treadmill to exhaustion in (d) 13-week old n = 15 Bcl6fl/fl and n = 14 Bcl6MKO male mice and (e) Cre- tmx and Bcl6i-MKO female mice twelve weeks after tamoxifen treatment (n = 12/group). (f, g) Light phase, dark phase and total activity in (f) 13-week old Bcl6fl/fl and Bcl6MKO male mice (n = 5/group) and (g) Cre- tmx and Bcl6i-MKO male mice 1.5 weeks after tamoxifen treatment (n = 5/group). All data in (c-g) are represented as mean + SEM. * p< 0.05.
