Extended Data Fig. 5: Decreasing osteocyte-derived sclerostin levels alleviates cognitive impairment and synaptic deficits in aged mice.
A-E. Assessment of athletic ability, anxiety, and depression. Heat map summary for the open field test (A). Athletic ability, including total distance (B) and average speeds (C), is shown. Anxiety and depression behaviors, including the distance traveled in the central area (D) and the time spent in the central area (E). (n = 10 Sost-WT male mice, n = 10 Sost-cKO male mice). Notes: Data are represented as mean ± SEM. Two-tailed unpaired t-test (B, C, D, E).
