Fig. 2: Genetic dissection of OXPHOS branching and reversibility.
From: PMF-seq: a highly scalable screening strategy for linking genetics to mitochondrial bioenergetics
a, Scatterplots of Z-scores of the specified respiratory chain components when glutamate/malate (first column), succinate (second column), or ascorbate/TMPD (third column) was used as the respiratory chain substrate in permeabilized A375 cells. b, Scatterplots of Z-scores of complex I (red) or complex V (black) when glutamate/malate (first column) or ATP (second column) was used as the substrate. Data from biological duplicates are shown. A highly negative Z-score indicates the enrichment of sgRNAs for a given gene in the low tail of the TMRM distribution, suggesting the dependency on that gene for membrane potential generation.
