Extended Data Fig. 3: Additional data related to Fig. 2a.
From: PMF-seq: a highly scalable screening strategy for linking genetics to mitochondrial bioenergetics
a, The 147 ‘Mitopathways’ gene sets are defined in the MitoCarta 3.0 database. The heatmap displays log base 10 p-values for each pathway, derived from overlap based on cumulative hypergeometric test statistics with a Z-score cutoff of −2 in PMF-seq experiments using glutamate/malate (left panel), succinate (middle panel), or ascorbate/TMPD (right panel) as substrates in A375 cells (Fig. 2a). b, Top hits in PMF-seq experiments as determined by the lowest mean Z scores from both replicates.
