Extended Data Fig. 5: LDHD loss does not greatly increase sensitivity to methylglyoxal toxicity. | Nature Metabolism

Extended Data Fig. 5: LDHD loss does not greatly increase sensitivity to methylglyoxal toxicity.

From: PMF-seq: a highly scalable screening strategy for linking genetics to mitochondrial bioenergetics

Extended Data Fig. 5

a, Mean Z scores for LDHD across screens. b, Cell counts of control and LDHD KO cells in A375 after 3 days of methylglyoxal treatment at the indicated dose. c, Viability of control and LDHD KO cells in the same samples as in (b). Shown is the mean +/- SD, n = 3. **p = 0.0016 indicates P values for the specified comparisons from two-way ANOVA after adjustment for multiple comparisons (Tukey’s).

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