Extended Data Fig. 5: Effects of maternal rhythm disruption on PPARγ signalling and mitochondrial function in neonatal PMN-MDSCs. | Nature Metabolism

Extended Data Fig. 5: Effects of maternal rhythm disruption on PPARγ signalling and mitochondrial function in neonatal PMN-MDSCs.

From: Maternal circadian rhythm disruption affects neonatal inflammation via metabolic reprograming of myeloid cells

Extended Data Fig. 5

(a) Heat map of genes related to oxidative phosphorylation in PMN-MDSCs (n = 3). (b) Diurnal mRNA expression of genes involved in mitochondrial dynamics in PMN-MDSCs from control and CRD groups was determined by qRT–PCR (n = 3/time point). (c) Heat map of PPARγ pathway related genes in PMN-MDSCs (n = 3). (d) qRT–PCR analysis of mitochondrial related genes in PMN-MDSCs from pups of PPARγfl/fl and PPARγfl/fl Lysmcre (n = 3). Data are representative of two independent experiments. Mean ± SEM were shown. Two-tailed unpaired Student’s t test for d. *p < 0.05; ***p < 0.001, exact P values are provided in the source data.

Source data

Back to article page