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Proteomics

Causal drivers of human proteome variation in health and disease

In this issue of Nature Metabolism, Carrasco-Zanini et al. describe sets of modifiable and non-modifiable drivers of human plasma proteins. These findings may inform the design of precision prevention programs and highlight novel therapeutic targets.

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Fig. 1: Data-driven analysis of risk factor–protein links and its causal effect on disease risk.

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Acknowledgements

P.W.F. and D.E.C. were supported by grants from the Swedish Research Council (2019-01348), the Swedish Foundation for Strategic Research (LUDC-IRC, 15-0067) and the European Commission (ERC-CoG_NASCENT - 681742).

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Correspondence to Paul W. Franks.

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Franks, P.W., Coral, D.E. Causal drivers of human proteome variation in health and disease. Nat Metab 6, 1854–1855 (2024). https://doi.org/10.1038/s42255-024-01138-0

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