Extended Data Fig. 10: Islet hormone contents is reduced in T1D. | Nature Metabolism

Extended Data Fig. 10: Islet hormone contents is reduced in T1D.

From: Loss of electrical β-cell to δ-cell coupling underlies impaired hypoglycaemia-induced glucagon secretion in type-1 diabetes

Extended Data Fig. 10

a-c, Violin plot of islet insulin (a), glucagon (b) and somatostatin (c) content in islets from ND and T1D donors (10 ND and 6 T1D donors for insulin and somatostatin and 20 ND and 6 T1D donors for glucagon). Different colours used for data from each donor. Insets show mean values of individual donors. **p = 0.005, ***p = 0.0005 and ****p < 0.0001 vs ND, two-sided Student’s t-test. d-e, Somatostatin (d) and glucagon secretion (e) at 1 mM glucose in islets from T1D donors in the absence and presence of 1 µM MFQ as indicated. Insets show average data for the individual donors. In dot plots, rectangles and error bars behind data points represent mean values ± S.E.M.

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