Fig. 7: Gut microbiota modulation improves MASH induced by intestinal Tm6sf2 deficiency. | Nature Metabolism

Fig. 7: Gut microbiota modulation improves MASH induced by intestinal Tm6sf2 deficiency.

From: Intestinal TM6SF2 protects against metabolic dysfunction-associated steatohepatitis through the gut–liver axis

Fig. 7: Gut microbiota modulation improves MASH induced by intestinal Tm6sf2 deficiency.The alternative text for this image may have been generated using AI.

a, Experimental schematic of microbiota modulation by co-housing male Tm6sf2∆IEC mice with male Tm6sf2fl mice for 4 months to restore the gut microbiota (n = 5 per group). b–e, Representative images of Oil Red O and H&E staining with histological scoring (b), hepatic levels of TNF and IL-6 (c), flow cytometric analysis of hepatic immune cell populations (d) and transmission electron microscopy (e) in Tm6sf2∆IEC and co-housed Tm6sf2∆IEC mice (n = 5 per group). Results are presented as the mean ± s.d. Statistical significance was determined by two-tailed Student’s t-test (b–e).

Source data

Back to article page